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Celebrex works by blocking the action of a substance in the body by inhibiting the breakdown of Celecoxib in the body by inhibiting the breakdown of Celecoxib in the body by inhibiting the breakdown of Celecoxib in the body called cyclo-oxygenase. Celecoxib is a non-steroidal anti-inflammatory drug. Celecoxib differs from other NSAIDs in that it causes less inflammation and ulceration of the stomach and intestine and does not interfere with the function of the blood platelets and, as a result, does not reduce clotting and lead to increased bleeding like other NSAIDs. Before using this medication, tell your doctor or pharmacist if you are allergic to it or to sulfa drugs. In clinical studies, a lower percentage of patients on Celebrex reported indigestion, abdominal pain, dyspepsia, diarrhea, nausea, flatulence and insomnia. Before taking Celecoxib, tell your doctor or pharmacist your medical history, especially of blood flow problem in the brain. When the benefits outweigh the potential risk to the fetus.