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Taking Esomeprazole? Esomeprazole works best if taken on an empty stomach at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. Esomeprazole works best if taken on an empty stomach at least one hour before a meal. Esomeprazole is available with a doctor's prescription and is commonly called by its brand name, Nexium. Taking Esomeprazole? Our Nexium prices are the lowest available online and updated monthly. What should my health care professional know before I take Esomeprazole? Taking Nexium should be part of your usual routine so that you do not forget to take it. Nexium is usually taken once a day at least one hour before meals and at the same time every day.
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