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Ciprofloxacin may be taken with food or on an empty stomach. The specific organisms causing your infection. Take Cipro tablet with a full glass of water and juices to increase drug's effectiveness and minimize adverse drug interaction. Cipro should not be taken with food or on an empty stomach. Ciprofloxacin is widely believed by physicians to be acceptable and relatively safe. Cipro can be taken with food or on an empty stomach.