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Hydrochlorothiazide increases the removal of salts from the blood, it also causes more water to be drawn out of the blood and into the urine. Hydrochlorothiazide increases the removal of salts from the blood, it also causes more water to be drawn out of the blood and into the urine. Hydrochlorothiazide has an additive effect on lowering blood pressure. Although there are no adequate and well-controlled studies using hydrochlorothiazide in pregnancy, thiazide diuretics may cause an increased risk of congenital defects. Hydrochlorothiazide may increase blood glucose levels. Some of the side effects that may occur while taking Microzide include black, tarry stools blood in urine or stools cough or hoarseness fever or chills joint pain lower back or side pain painful or difficult urination. Hydrochlorothiazide may increase the blood level of the medicine lithium, and this medicine is used to treat high blood pressure. The management of hypertension and has proven to be of benefit in terms of cardiovascular outcome If you miss a dose of Hydrochlorothiazide and are using it regularly, take it as soon as possible.