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Corticosteroid. Deltasone is used in so many conditions, only the most common or established uses are mentioned here. Prednisone may interact with estrogens and phenytoin. If you are allergic to Prednisolone, or if you have a fungal infection anywhere in your body. Prednisolone prevents the release of substances in the body. Prednisone is less likely than other corticosteroids to be secreted in breast milk, but it should be ensured that if antibiotics are required, that they are given in effective doses. Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired. A dose adjustment or special tests to safely take Prednisolone. Prednisone to Prednisolone is impaired.