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Paxil is safe and effective for long-term use and is well tolerated. Paxil has been approved by the FDA as a safe and effective for long-term use and is well tolerated. Paxil is well established in treating depression after nearly ten years and over ten million patient treatments. Zoloft, Paxil, Luvox and Prozac are currently used by more than five million Americans. Do not take Paxil without first talking to your doctor if you experience headache nervousness, or anxiety nausea, diarrhea, or changes in appetite or weight.
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