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Cephalexin may be given on an empty stomach or with food to prevent stomach upset. Keflex is a semi-synthetic cephalosporin antibiotic for oral administration. Keflex is a cephalosporin antibiotic used to treat bacterial infections of the skin, urinary tract, respiratory tract, bones, and joints. Patients with known allergy to the cephalosporin group of antibiotics. Cephalexin is a broad-spectrum antibiotic used to treat a wide variety of bacterial infections. This medication. Antibiotics, although some side effects can be serious. Cephalexin may be given on an empty stomach or with food to prevent stomach upset.