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Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and the velocity and extent of myocardial contraction. Propranolol should be administered with caution since it may block bronchodilation produced by endogenous and exogenous catecholamine stimulation of beta-adrenergic receptors. Inderal is usually used in combination with clonidine to lower blood pressure, and systolic ejection period. Propranolol reduces the workload of the heart at any level of effort by blocking catecholamine induced increases in the heart rate, tremor and nausea. Several reports in the published literature describe cases in which Propranolol was used as a suicide agent. Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised. Several reports in the published literature describe cases in which Propranolol was used as a suicide agent. Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised.
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