An appetite-suppressant medication. Levothyroxine tablets were taken with water. Differences of only a few micrograms of Synthroid can make a large difference in how you feel. If you need to be observant of possible side effects for this reason the correct dose of Synthroid is difficult to find. The same time every day. An empty stomach, one-half to one hour before breakfast. Most of these problems disappeared when levothyroxine tablets were taken with water. Synthroid may rapidly swell and disintegrate resulting in choking, gagging, the tablet getting stuck in your throat, or difficulty swallowing.
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