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Ketoconazole reaches the surface of the skin through normal blood circulation. The concentration of Warfarin and triazolam and enhance their effect. Ketoconazole can be used in the treatment of Cushing's disease, where an excess amount of adrenal hormone is produced. Very high concentrations of the drug develop within the skin, so it is effective in treating superficial fungal infections. Ketoconazole is absorbed into the body best when it is taken with a fatty meal or acidic drink like orange juice.
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